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TEAMLAB PUBLICATIONS

2024 PUBLISHED

Adjei, N, Haas, A, Sun, C, et al. Cost of ovarian cancer by the phase of care in the United States. 2024. American Journal of Obstetrics & Gynecology Read More

Aguirre, A, Stanger, B, Maitra, A, et al. Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer. 2024. Cancer Research. Read More

Bahrambeigi, V, Lee, J, Branchi, V, et al. Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype. 2024. Cancer Research. Read More

Braxton, A, Kiemen, A, Grahn, M, et al. 3D genomic mapping reveals multifocality of human pancreatic precancers. 2024. Nature. Read More

Chien, Y, Wang, Y, Huang, P, et al. Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions. 2024. The American Journal of Surgical Pathology. Read More

Dilly, J, Hoffman, M, Abbassi, L, et al. Mechanisms of resistance to oncogenic KRAS inhibition in pancreatic cancer. 2024. Cancer Discovery. Read More

Jiang, J, Liu, Y, Qin, J, et al. METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics. 2024. Nature Communications. Read More

Kiemen, A, Wu, P, Braxton, A, et al. Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings. 2024. Science Advances. Read More

Shi, H, Williams, M, Satas, G, et al. Allele-specific transcriptional effects of subclonal copy number alterations enable genotype-phenotype mapping in cancer cells. 2024. Nature Communications. Read More

Singhal, A, Styers, H, Rub, J, et al. A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer. 2024. Cancer Discovery. Read More

Wang, Y, Douville, C, Chien, Y, et al. Aneuploidy Landscape in Precursors of Ovarian Cancer. 2024. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research. Read More

Wasko, U, Jiang, J, Dalton, T, et al. Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer. 2024. Nature. Read More

Yen, J, Wu, T, Stone, R, et al. Salpingectomy for ectopic pregnancy reduces ovarian cancer risk—a nationwide study. 2024. JNCI Cancer Spectrum. Read More

Zhang, D, Schroeder, A, Yan, H, et al. Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology. 2024. Nature Biotechnology. Read More

2024 PRE-PRINT

Chukwu, W, Lee, S, Crane, A, et al. Comparison of germline and somatic structural variants in cancers reveal systematic differences in variant generating and selection processes. 2024. (preprint – bioRxiv) Read More

Huang, J, Yuan, C, Jiang, J, et al. MorphLink: Bridging Cell Morphological Behaviors and Molecular Dynamics in Multi-modal Spatial Omics. 2024. (preprint – bioRxiv) Read More

Kiemen, A, Almagro-Pérez, C, Matos, V, et al. 3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure. 2024. (preprint – bioRxiv) Read More

Uryu, H, Saeki, K, Haeno, H, et al. Clonal evolution of hematopoietic stem cells after cancer chemotherapy. 2024. (preprint – bioRxiv) Read More

Wala, J, Bruijn, I, Coy, S, et al. Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers. 2024. (preprint – bioRxiv) Read More

Williams, M, Vazquez-Garcia, I, Tam, G, et al. Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA. 2024. (preprint – bioRxiv) Read More

Xu, E, Smith, B, Alberto, W, et al. Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells. 2024. (preprint – bioRxiv) Read More

Zhang, C, Pellman, D, et al. Chromosome breakage-replication/fusion enables rapid DNA amplification. 2024. (preprint – bioRxiv) Read More

Zhang, H, Sashittal, P, Karnoub, E, et al. Genomic evolution of pancreatic cancer at single-cell resolution. 2024. (preprint – bioRxiv) Read More

2023 PUBLISHED

Han, J, Xu, J, Liu, Y, et al. Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer. 2023. Genes & Development. Read More

Jazaeri, A, Grisham, R, Knisely, A, et al. Transforming ovarian cancer care by targeting minimal residual disease. 2023. Med. Read More

Mahadevan, K, LeBleu, V, Ramirez, E, et al. Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells. 2023. Developmental Cell. Read More

Mahadevan, K, McAndrews, K, LeBleu, V, et al. KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells. 2023. Cancer Cell. Read More

Stone, R, Sakran, J, Long Roche, K, et al. Salpingectomy in Ovarian Cancer Prevention. 2023. JAMA. Read More

Taylor, M, Wu, C, Fridy, P, et al. Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker. 2023. Cancer Discovery. Read More

Zhang, H, Hunter, M, Chou, J, et al. BayesTME: An end-to-end method for multiscale spatial transcriptional profiling of the tissue microenvironment. 2023. Cell Systems. Read More

Zhao, Y, O’Keefe, C, Hsieh, K, et al. Multiplex Digital Methylation‐Specific PCR for Noninvasive Screening of Lung Cancer. 2023. Advanced Science. Read More

2023 PRE-PRINT

Brodeur, M, Dopeso, H, Zhu, Y, et al. Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity. 2023. (preprint – bioRxiv) Read More

Dalin, S, Webster, S, Sugawara, N, et al. Double-strand break repair-associated intragenic deletions and tandem duplications suggest the architecture of the repair replication fork. 2023. (preprint – bioRxiv) Read More

Mahadevan, K, McAndrews, K, LeBleu, V, et al. Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner. 2023. (preprint – bioRxiv) Read More

Perelli, L, Zhang, L, Mangiameli, S, et al. Evolutionary fingerprints of EMT in pancreatic cancers. 2023. (preprint – bioRxiv) Read More

Rendo, V, Schubert, M, Khuu, N, et al. A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer. 2023. (preprint – bioRxiv) Read More

Yu, K, Basu, S, Baquer, G, et al. Investigative needle core biopsies for multi-omics in Glioblastoma. 2023. (preprint – medRxiv) Read More

2022 PUBLISHED

Chatterjee, F, Duong, E, Bhutkar, A, et al. 994 Investigating the ability of tumor cell-derived type I interferon to potentiate anti-ovarian cancer immune responses. 2022. Journal for ImmunoTherapy of Cancer. Read More

Liberto, J, Chen, S, Shih, I, et al. Current and Emerging Methods for Ovarian Cancer Screening and Diagnostics: A Comprehensive Review. 2022. Cancers. Read More

Mandal, J, Mandal, P, Wang, T, et al. Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response. 2022. Journal of Biomedical Science. Read More

2022 PRE-PRINT

Kinny-Köster, B, Guinn, S, Tandurella, J, et al. Inflammatory Signaling in Pancreatic Cancer Transfers Between a Single-cell RNA Sequencing Atlas and Co-Culture. 2022. (preprint – bioRxiv) Read More

NEWS COVERAGE

The launch of a new foundation called Break Through Cancer was announced

M.D. Anderson, four other hospitals launch national cancer research foundation with $250M gift

5 US cancer centers launch major research initiative: 6 things to know

5 Leading Research Institutions to Target Toughest Cancers With New Public Foundation

The Cancer Letter Conversation with The Cancer Letter

Remarks by President Biden at an Event Commemorating the 50 Millionth COVID-19 Vaccine Shot

Break Through Cancer launches collaborative model across top U.S. research institutions in pursuit of cancer cures

VIDEO CLIPS

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PRESS RELEASES

Break Through Cancer Summit Advances ‘Radical Collaboration’ Among Top Cancer Centers

Break Through Cancer Launches Two TeamLabs Targeting Acute Myelogenous Leukemia (AML)

Break Through Cancer, A New Research Consortium, Names First Class of Scientists Designated as Catalysts for Innovation and Collaboration

MD Anderson receives over $10 million from Break Through Cancer to support collaborative research with leading cancer centers

MD Anderson receives over $10 million from Break Through Cancer to support collaborative research with leading cancer centers Funding is part of $50...

Break Through Cancer Announces $50M in Grants to Empower Researchers from Five Top Cancer Research Centers to Work as One

New cancer research foundation will help accelerate discoveries in glioblastoma, ovarian, and pancreatic cancers using a bold new approach. CAMBRIDGE, Mass., April 19,...

Break Through Cancer Launches Collaborative Model

Break Through Cancer Launches Collaborative Model Across Top U.S. Research Institutions in Pursuit of Cancer Cures New foundation brings together teams from Dana-Farber...

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