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Break Through Cancer is a 501(c)3. We are a growing team based in Cambridge, MA. We offer full benefits, competitive salaries, and are committed to equal opportunities in employments. Learn more about our open positions below.
To apply for any of these positions please submit a cover letter and CV or resume to

Break Through Cancer is a new type of foundation that empowers outstanding researchers and physicians to intercept, as well as find cures, for the deadliest cancers by stimulating radical collaboration. BTC is a first-of-its-kind collaboration of five of the top cancer research centers in the world: Dana-Farber Cancer Institute, Johns Hopkins Sidney Kimmel Comprehensive Cancer Center, MIT’s Koch Institute for Integrative Cancer Research, The University of Texas MD Anderson Cancer Center, and Memorial Sloan Kettering Cancer Center. Break Through Cancer is focused on several of the world’s deadliest cancers: initially glioblastoma, AML, ovarian, and pancreas cancers. These are diseases with poor prognoses for which progress has been very slow. We are looking beyond conventional therapies, utilizing new strategies, structures, and thinking from across disciplines, with the goal of enabling discoveries at an unprecedented pace. Since its inception in 2021, Break Through Cancer has made investments totaling over $100M in an ambitious scientific portfolio.

Making project teams across five institutions function as if they were all working within the same laboratory requires world-class program management, including strengthening relationships and alliances, overseeing compliance/IRB and intellectual property obligations, and managing projects and deliverables to succeed on appropriate timelines. Projects include substantial executional complexity including complex relationships with academic, hospital, and industry partners. Resolving complexity and engaging scientific teams closely to empower project teams and deliver impact is critical to Break Through Cancer’s success.

Data Science Engineer

Alongside many of the finest minds in cancer research, you will tackle some of the hardest open problems in areas of greatest unmet need and apply the results directly to patient treatment across the nation. Part of what makes Break Through Cancer compelling is our founding principle that computational methods and data are an integral part of the entire research, development, and treatment process—not merely a quantitative afterthought. This ethos is codified into the design of our first-of-kind Data Science Hub, which aims to rapidly unify the most advanced patient and molecular data with analysis methods and visual tools to analyze and explore them, making all of it accessible in as timely, frictionless, and simple manner as possible––regardless of one’s level of technical sophistication. As an enabler of biological discovery and facilitator of patient treatment, the Data Science Hub will be a vital strategic asset in our portfolio and bedrock element of all disease research teams and clinical efforts.

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Position Summary:
In this role you will provide data engineering and software development expertise to interdisciplinary projects ranging from basic research & discovery to clinical sample processing & analysis and machine learning models. Motivated by the chance to help decipher fundamental biological processes that directly impact patient outcomes, the ideal candidate will exude a deep passion for science and through this will:

  • co-develop and/or maintain pipelines, software, databases and/or UIs for such
  • embrace collecting, annotating & shepherding access to internal & external data
  • prioritize data credibility towards the extraction of actionable scientific insight
  • continuously optimize scalability, software & data quality, and internal SOPs
  • harden, benchmark, and deploy cutting-edge bio-informatic methods
  • iterate with stakeholders on requirements gathering to identify & fill gaps in data, software tools and documentation
  • The Ideal Candidate Would Possess These Experiences and Skills
    • B.S or M.S. degree in CS, Math, or Bioinformatics; Biology candidates with considerable evidence of successful coding experience may be considered
    • 2-5+ years’ experience in similar role (clinical/biotech/pharma setting a big plus)
    • Strong coding proficiency in Python and/or R; evidence of experience with HTML, JavaScript, UNIX shell & Java would be strong pluses
    • Proficiency in SQL databases (Postgres preferred; NoSQL a plus) & extracting insight from evolving or unstructured data into warehouse
    • Proficiency in developing /using APIs to collect data, process & compute upon it
    • Experience with public datasets used in biomedical research
    • Experience performing root cause of failure analysis on data & processes to answer specific research questions or identify opportunities for improvement
    • Portals for data visualization & dashboarding with Jupyter, PANDAS, Streamlit, R/Shiny
    • High-throughput computation on cloud infrastructure (preferably GCP and/or AWS)
    • Strong oral & written communication skills, and attention to detail
    • Capable of working from incomplete information, without micromanagement
    • Able to systematically prioritize deliverables across multiple projects
    • Strong drive and resilience in the face of challenges, with positive attitude
    • Evidence of ability to translate external software tools, data repositories or research publications into concrete deliverables aligned with organizational goals

    Proficiency In or Exposure to the Following Would be Strong Pluses

  • NextFlow, CWL, WDL workflow orchestration languages
  • Terra, Synapse, CodeOcean, Foundry data management & analysis systems
  • Storage, pipelined analysis, and interpretation of large-scale:
    • DNA and RNA sequence data (bulk and single cell)
    • spatial profiling and pathology image data
    • clinical data elements
  • Multi-omic bioinformatics, statistics, data cleansing, integration, and analysis
  • Biomarker discovery, clinical trial sample processing and analysis
  • Cloud and/or big data toolchains: Docker, Kubernetes, Spark, Kafka, Hadoop
  • Oncology, immunology, immunotherapies for cancer

Scientific Portfolio Manager

Break Through Cancer seeks an organized, passionate, and enthusiastic Scientific Portfolio Manager to report to the Senior Director, Science Programs. The primary responsibilities of this role will be to work closely with Break Through Cancer virtual research communities called “TeamLabs” to manage timelines, deliverables, and expenditures for specific project(s) and to support Break Through Cancer-funded scientists to proactively identify and overcome key executional barriers.

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Responsibilities include:

  • Working closely with the Chief Science Officer, BTC Scientific Portfolio Managers, and members of funded teams to monitor the implementation of scientific and clinical plans, and assist where necessary;
  • Working closely with the Chief Operations Officer and administrators at the Partner Institutions to understand and facilitate solutions for operational challenges;
  • Proactively identify cross-institutional research challenges and develop solutions for timely resolution of risks/issues (e.g. management of human subjects, intellectual property, material transfer agreements, contingencies, timelines, and resources);
  • Overseeing the annual strategic planning and budgeting process for each TeamLab in collaboration with the Chief Financial Officer and the Scientific Portfolio Managers; Developing metrics that focus on measuring success, scalability, cost effectiveness, and overall process efficiencies of the BTC Portfolio;
  • Ensuring that TeamLabs are managed consistently, drive implementation of program management best practices, standard tools, and approaches, and partnering with the Chief Science Officer to convene and manage TeamLab Steering Committees; and
  • Working closely with the Senior Director of Strategic Alliances and members of the BTC Industry Partner Alliance (IPA) to ensure the successful scientific and operational implementation of IPA project plans within each TeamLab;
  • Other duties as required.Qualifications
  • 7 years of experience in operational leadership for a complex scientific organization and/or project management in a highly matrixed organization;
  • Master’s degree or MBA required; PhD a plus
  • Deep understanding of biomedical research;
  • Experience working with and managing cross-functional teams;
  • Strong facilitation, problem-solving, and conflict/issue resolution skills;
  • Adaptive leadership style with ability to influence teams without formal authority; demonstrated ability to collaborate across multiple stakeholder groups;
  • Excellent interpersonal /relationship management skills and proven ability to facilitate internal/external alignment; and

Excellent verbal and written communication skills

To apply for this position, please submit a cover letter and cv to: In your cover letter, please answer the following:

  1. What has motivated you to apply for the Senior Director, Science Programs role at Break Through Cancer, and in particular, what inspires you to work for a foundation that is dedicated to cancer research?
  2. Describe your experience leading and managing multi-institutional collaborations
  3. Provide examples of how you have navigated politically complex and matrixed environments

Break Through Cancer is committed to providing equal opportunities in employment and prohibits discrimination and harassment of any kind. We treat our fellow Break Through Cancer colleagues and applicants fairly and respectfully. We seek to employ people with skill and integrity, and provide them with the means to develop professionally. We hire without regard to race, color, religion, creed, citizenship, national origin, age, sex, gender, pregnancy, gender identity/ expression, sexual orientation, marital status, disability (including neurodiversity), genetic information, veteran status, and any other legally protected group, in accordance with applicable federal, state, or local law.


Break Through Cancer was created in February 2021 with an extraordinary matching gift of $250,000,000. Every gift to the Foundation supports groundbreaking cancer research and helps us to meet our matching commitment.

For questions about giving please email Lisa Schwarz, Chief Philanthropy Officer at

Break Through Cancer
101 Rogers Street
Suite 3A
Cambridge, MA 02142