Real-Time Biopsies Uncover Hidden Response to Glioblastoma Therapy Early clinical trial results show that serial brain biopsies reveal immune activity in brain cancer not captured by standard scans News Release For Immediate Release Media Contact: Soracha Ward soracha.ward@breakthroughcancer.org (CAMBRIDGE, MASS.) October 08, 2025 – A new study led by Break Through Cancer’s Accelerating Glioblastoma (GBM) Therapies Through Serial Biopsies TeamLab has revealed that an engineered virus therapy, CAN-3110, triggered powerful immune responses deep inside glioblastoma tumors that were invisible to standard imaging like MRI, according to early analyses of two patients with recurrent GBM. Published today in Science Translational Medicine,......

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New Blood-Based Technology Tracks Tumor Evolution in Ovarian Cancer Patients Break Through Cancer researchers uncover hidden cell populations driving relapse — findings could pave the way for more targeted treatments News Release For Immediate Release Media Contact: Soracha Ward soracha.ward@breakthroughcancer.org (CAMBRIDGE, MASS.) October 01, 2025 – A new study published in Nature uncovers how ovarian cancers evolve during treatment, and how blood samples taken throughout disease progression could help guide therapies more effectively. The research shows that drug-resistant cancer cell populations may exist long before treatment begins, and that tracking these populations over time can reveal vulnerabilities that may be......

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New Study Finds Hidden Disease in Nearly Half of Ovarian Cancer Patients in ‘Remission’ Using minimally invasive surgery and blood tests Break Through Cancer TeamLab found cancer cells, new drug targets, and biological clues for future therapies News Release For Immediate Release Media Contact: Soracha Ward soracha.ward@breakthroughcancer.org (CAMBRIDGE, MASS.) August 01, 2025 – Survival rates for advanced ovarian cancer have remained stagnant for over four decades, largely because it so often recurs. While patients respond well to initial surgery and chemotherapy, it comes back in 4 out of 5 cases. A new Break Through Cancer study published in Clinical Cancer......

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Can Early Intervention Prevent Leukemia? New Trial Gives Patients a Choice Beyond the Current ‘Wait and See’ Approach Scientists are exploring if early intervention can prevent AML in high-risk patients, shifting the focus from monitoring to proactive prevention News Release For Immediate Release Media Contact: Soracha Ward soracha.ward@breakthroughcancer.org (CAMBRIDGE, MASS.) July 10, 2025 – Break Through Cancer, a Boston-based cancer research foundation, has launched a clinical trial to evaluate the feasibility of early intervention for Clonal Hematopoiesis (CH), a precursor to acute myeloid leukemia (AML). This multi-institutional study focuses on high-risk patients, exploring a new approach to managing this pre-malignant......

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Small Biopsies, Big Insights: How Tiny Tissue Samples Could Transform Glioblastoma Research New study from Break Through Cancer TeamLab unveils the power of investigational biopsies, unlocking a promising tool for real-time monitoring of glioblastoma News Release For Immediate Release Media Contact: Soracha Ward soracha.ward@breakthroughcancer.org (CAMBRIDGE, MASS.) April 30, 2025 – Glioblastoma (GBM) is a highly aggressive form of brain cancer, leaving patients with limited treatment options. In a new study published in Nature Communications, the Break Through Cancer Accelerating GBM Therapies Through Serial Biopsies TeamLab has demonstrated how “investigative biopsies” can unlock critical insights into tumor biology. To address the......

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Break Through Cancer and Revolution Medicines Collaborate to Study Biomarkers for RAS(ON) Inhibitor in Pancreatic Cancer News Release For Immediate Release Media Contact: Kari McHugh Kari.McHugh@breakthroughcancer.org Collaboration with Revolution Medicines to Study Biomarkers for RAS(ON) Multi-Selective Inhibitor in Pancreatic Cancer The expanded phase 1 clinical trial is using serial biopsies and blood samples to analyze the tumor response to RMC-6236 at an unprecedented level of detail.   (CAMBRIDGE, MASS.) December 19, 2024 – Break Through Cancer has launched a collaborative cohort for a Phase 1 study of RMC-6236, a compound developed by Revolution Medicines that is designed to suppress multiple......

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News Release For Immediate Release Media Contact: Kari McHugh Kari.McHugh@breakthroughcancer.org   Break Through Cancer Announces First Patient Enrolled in Phase 2 Trial  Targeting Residual Disease in AML The novel study explores the effects of menin inhibition in acute myeloid leukemia with minimal residual disease as an endpoint. (CAMBRIDGE, MASS.) November 1, 2024 – Break Through Cancer, a Boston-based cancer research foundation, has launched a clinical trial to explore if an investigational drug can eliminate minimal residual disease (MRD) in acute myeloid leukemia (AML). AML often responds well to initial treatment, but residual cancer cells frequently cause relapse. Break Through Cancer’s......

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