Back to the top

Clues to Why a Breakthrough Pancreatic Cancer Drug Eventually Stops Working | The New York Times

Clues to Why a Breakthrough Pancreatic Cancer Drug Eventually Stops Working September 30, 2026 | The New York Times Gina Kolata Researchers are asking why patients, like former Senator Ben Sasse, inevitably develop resistance to the drug daraxonrasib. The work involved an unusual effort by three groups: Break Through Cancer, a nonprofit that brings researchers together to tackle challenging problems in cancer treatment; the Lustgarten Foundation, which supports research on pancreatic cancer; and Revolution Medicines, which makes daraxonrasib. Read the full story on The New York Times...

Continue reading

We can prevent ovarian cancer. Women deserve the option. | USA Today

We can prevent ovarian cancer. Women deserve the option. | Opinion August 13, 2026 | USA Today Dr. Joseph Sakran and Dr. Rebecca Stone Cancer prevention opportunities are rare. When one presents itself safely during an operation a patient is already having, we have a responsibility to consider it. Read the full story on USA Today...

Continue reading

Most ‘Ovarian Cancer’ Isn’t. And That Fact Can Save Lives | New York Times

Most ‘Ovarian Cancer’ Isn’t. And That Fact Can Save Lives. The vast majority of cases begin in the fallopian tubes — and removing them can reduce the risk by nearly 80 percent. July 28, 2026 | Gina Kolata   Kira Wynn will do almost anything to avoid ovarian cancer, which killed her mother. “My mom thought she’d pulled a muscle in her side,” Ms. Wynn said. Her mother’s doctor, she added, “told her to do physical therapy.” As is often the case with ovarian cancer, Ms. Wynn’s mother’s disease was already at an advanced stage when she was diagnosed. She......

Continue reading

Breaking Through Pancreatic Cancer with Revolution Medicines

Breaking Through Pancreatic Cancer with Revolution Medicines For decades, RAS mutations drove more than 90% of pancreatic tumors with no viable therapeutic target. That is now changing. Break Through Cancer's Conquering KRAS in Pancreatic Cancer TeamLab has spent years generating deep molecular data on advanced pancreatic cancer in the laboratory and through a first-of-its-kind clinical trial assessing daraxonrasib – an investigational multi-selective RAS(ON) inhibitor. The TeamLab's clinical trial studies paired pre- and on-treatment biopsies and blood samples to understand how tumors respond, adapt, and resist at the molecular level. In this conversation, Mark Goldsmith, MD, PhD, Chief Executive Officer of......

Continue reading

Break Through Cancer and the Lustgarten Foundation Launch New Pancreatic Cancer Initiative | The ASCO Post

Break Through Cancer and the Lustgarten Foundation Launch New Pancreatic Cancer Initiative July 02, 2026 | The ASCO Post Staff At a pivotal moment for pancreatic cancer, Break Through Cancer and the Lustgarten Foundation, with support from the Cinelli Family Foundation, has announced a $16 million investment in the Conquering KRAS for Patients with Pancreatic Cancer TeamLab. Spanning six world-class cancer research institutions, this initiative aims to improve outcomes for one of the deadliest cancers by focusing on KRAS, a gene that is mutated in more than 90% of pancreatic cancer cases. Read More The ASCO Post....

Continue reading

How scientists found a weakness in one of the deadliest ‘undruggable’ cancers | The Washington Post

How scientists found a weakness in one of the deadliest 'undruggable' cancers May 24, 2026 | Calrolyn Johnson “This is the news we've been waiting for. This is the breakthrough — it's been a long time coming,” said Break Through Cancer President Tyler Jacks, PhD, in a recent Washington Post feature examining the decades-long scientific effort that led to KRAS-targeted therapies for pancreatic cancer. In this new article for The Washington Post, Carolyn Johnson traces the scientific journey behind daraxonrasib, from the early discovery of KRAS as a cancer driver to the clinical results that are reshaping expectations for one......

Continue reading

Radical Collaboration: A Cancer Funder Seeks to Solve the Problem of Siloed Research | Inside Philanthropy

Radical Collaboration: A Cancer Funder Seeks to Solve the Problem of Siloed Research April 20, 2026 | Paul Karon Back in 2021, I wrote about Break Through Cancer, then a newly launched organization focused on addressing a literally deadly problem: overly siloed, disconnected research on the second-leading cause of death in the U.S. and worldwide. Beyond funding research, Break Through Cancer’s leaders seek to create a more effective way to build and operate research teams that span multiple specialties, labs and institutions — the better to untangle cancer’s toughest challenges and develop better ways to diagnose and treat patients. While collaboration between......

Continue reading

Why some family offices are becoming cancer research’s new bankrollers | Crain Currency

Why some family offices are becoming cancer research's new bankrollers March 13, 2026 | Marcus Baram Family offices are stepping in to fill a widening gap in cancer research funding, deploying billions of dollars of patient capital at a moment when federal cuts threaten to stall laboratories and AI breakthroughs promise to accelerate drug development. Read More at Crain Currency....

Continue reading

Break Through Cancer’s Tyler Jacks: “We’ve created a new operating model for collaborative cancer research. | The Cancer Letter

Break Through Cancer’s Tyler Jacks: “We’ve created a new operating model for collaborative cancer research. March 13, 2026 | Vol.52 No.10 Five years ago, Tyler Jacks took on a new challenge, becoming president of Break Through Cancer, a foundation that has pledged to spend at least $500 million to support research projects across top tier cancer centers. From the start, the foundation’s objective included fostering a change in culture in America’s top labs, ushering in what Jacks calls “radical collaboration” (The Cancer Letter, Feb. 25, 2021). Read More at The Cancer Letter. Watch Tyler's Conversation with Paul here:...

Continue reading

Break Through Cancer
101 Rogers Street
Suite 3A
Cambridge, MA 02142
Info@breakthroughcancer.org
1-800-757-9881

Charity Navigator Four Star Rating