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Breaking Through Pancreatic Cancer with Revolution Medicines

Breaking Through Pancreatic Cancer with Revolution Medicines For decades, KRAS mutations drove more than 90% of pancreatic tumors with no viable therapeutic target. That is now changing. Break Through Cancer's Conquering KRAS in Pancreatic Cancer TeamLab has spent years generating uniquely deep molecular data on advanced pancreatic cancer in the laboratory and through a first-of-its-kind clinical trial assessing daraxonrasib — a pan-RAS inhibitor developed by Revolution Medicines that has demonstrated a near doubling of survival in metastatic pancreatic cancer. The TeamLab's clinical trial studies paired pre- and on-treatment biopsies and blood samples to understand how tumors respond, adapt, and resist......

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2025 Year in Review: Our Scientific Progress and Clinical Impact

Accelerating Discovery: Break Through Cancer’s 2nd Annual Hackathon Break Through Cancer’s 2025 Year in Review captures a year of measurable scientific progress across our TeamLabs, from advancing multi-site clinical trials to scaling data infrastructure and publishing high-impact research. Together, these efforts reflect the power of radical collaboration™ to drive progress against the deadliest cancers. 📖 Explore the 2025 Year in ReviewJTNDaWZyYW1lJTIwYWxsb3dmdWxsc2NyZWVuJTNEJTIyYWxsb3dmdWxsc2NyZWVuJTIyJTIwYWxsb3clM0QlMjJjbGlwYm9hcmQtd3JpdGUlMjIlMjBzY3JvbGxpbmclM0QlMjJubyUyMiUyMGNsYXNzJTNEJTIyZnAtaWZyYW1lJTIyJTIwc3JjJTNEJTIyaHR0cHMlM0ElMkYlMkZoZXl6aW5lLmNvbSUyRmZsaXAtYm9vayUyRmY4YWIyYzllYzkuaHRtbCUyMiUyMHN0eWxlJTNEJTIyYm9yZGVyJTNBJTIwMXB4JTIwc29saWQlMjBsaWdodGdyYXklM0IlMjB3aWR0aCUzQSUyMDEwMCUyNSUzQiUyMGhlaWdodCUzQSUyMDQwMHB4JTNCJTIyJTNFJTNDJTJGaWZyYW1lJTNF 📖 Watch the 2025 Highlight Video...

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Accelerating Discovery: 𝖡𝗋𝖾𝖺𝗄 𝘛𝘩𝘳𝘰𝘶𝘨𝘩 𝖢𝖺𝗇𝖼𝖾𝗋’𝗌 2nd Annual Hackathon

Accelerating Discovery: Break Through Cancer’s 2nd Annual Hackathon This June, Break Through Cancer hosted its 2nd Annual Hackathon at the Broad Institute, bringing together 67 participants across seven TeamLabs for two days of intense, cross-disciplinary problem solving. Researchers, clinicians, data coordinators, and Break Through Cancer staff worked side by side to tackle some of the most pressing analytical challenges across glioblastoma, ovarian, and pancreatic cancer.   Radical Collaboration in Action Hackathons are designed to spark innovation by bringing together people who don’t normally sit in the same room. For Break Through Cancer, they are a natural extension of our TeamLab......

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