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PRESS RELEASES

Real-Time Biopsies Uncover Hidden Response to Glioblastoma Therapy

New Blood-Based Technology Tracks Tumor Evolution in Ovarian Cancer Patients

American Cancer Society and Break Through Cancer Unite to Outsmart Ovarian Cancer

Break Through Cancer Launches Largest-Ever Investment in Pediatric Osteosarcoma Research

New Study Finds Hidden Disease in Nearly Half of Ovarian Cancer Patients in ‘Remission’

Can Early Intervention Prevent Leukemia? New Trial Gives Patients a Choice Beyond the Current ‘Wait and See’ Approach

Small Biopsies, Big Insights: How Tiny Tissue Samples Could Transform Glioblastoma Research

Break Through Cancer and Revolution Medicines Collaborate to Study Biomarkers for RAS(ON) Inhibitor in Pancreatic Cancer

IN THE NEWS

Real-Time Biopsies Reveal Hidden Insights into Glioblastoma Therapy Response | Bioengineer.org

Experimental Glioblastoma Trial Findings Could Lead to Change in Patient Monitoring and Therapy | GEN

Serial Biopsies Reveal Immune Activation During Treatment for Recurrent Glioblastoma | Gene Online

Break Through Cancer launches a $15M multi-institute pediatric osteosarcoma research initiative | The Cancer Letter

Can a virtual team of researchers break a 40-year logjam in this rare cancer? | Endpoints News

Detecting minimal residual disease may be key to preventing ovarian cancer recurrence | Healio

A New Approach to Undetectable Ovarian Cancer | Targeted Oncology

The Prognostic Value of Residual Disease in Ovarian Cancer | Targeted Oncology

TEAMLAB PUBLICATIONS

2025 PUBLISHED

Huffman B, Rahma O, Tyan K et al. A Phase I Trial of Trebananib, an Angiopoietin 1 and 2 Neutralizing Peptibody, Combined with Pembrolizumab in Patients with Advanced Ovarian and Colorectal Cancer. 2025. Cancer Immunology Research. Read More

Liu Y, Han J, Hsu W et al. Combined KRAS Inhibition and Immune Therapy Generates Durable Complete Responses in an Autochthonous PDAC Model. 2025, Cancer Discovery. Read More

Tosh C, Tec M, White J et al. A Bayesian active learning platform for scalable combination drug screens. 2025. Nature Communications. Read More

Varghese A, Perry M, Chou J, et al. Clinicogenomic landscape of pancreatic adenocarcinoma identifies KRAS mutant dosage as prognostic of overall survival. 2025. Nature Medicine. Read More

Coleman K, Schroeder A, Loth M et al. Resolving tissue complexity by multimodal spatial omics modeling with MISO. 2025. Nature Methods. Read More

Rendo V, Schubert M, Khuu N et al. A compendium of Amplification-Related Gain Of Sensitivity genes in human cancer. 2025. Nature Communications. Read More

Adjei N, Haas A, Sun C et al. Healthcare Costs in the United States by Demographic Characteristics and Comorbidity Status. 2025. Value in Health. Read More

Chukwu W, Lee S, Crane A et al. A sequence context-based approach for classifying tumor structural variants without paired normal samples. 2025. Cell Reports Methods. Read More

Perelli L, Zhang L, Mangiameli S et al. Evolutionary fingerprints of epithelial-to-mesenchymal transition. 2025. Nature. Read More

Guo M, Fuh K and Stone R. New opportunities for opportunistic salpingectomy: Leveraging non-gynecologic surgeries for ovarian cancer prevention. 2025. Gynecologic Oncology Reports. Read More

Lvovs D, Creason A, Levine S et al. Balancing ethical data sharing and open science for reproducible research in biomedical data science. 2025. Cell Reports Medicine. Read More

Pei G, Min J, Rajapakshe K et al. Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer. 2025. Nature. Read More

Yu K, Basu S, Baquer G et al. Investigative needle core biopsies support multimodal deep-data generation in glioblastoma. 2025. Nature Communications. Read More

Takao S, Morell V, Uni M et al. Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance. 2025. Nature Communications. Read More

Xie A, Tansey W and Reznik E. UnitedMet harnesses RNA–metabolite covariation to impute metabolite levels in clinical samples. 2025. Nature Cancer. Read More

Liu Y, Sinjab A, Min J et al. Conserved spatial subtypes and cellular neighborhoods of cancer-associated fibroblasts revealed by single-cell spatial multi-omics. 2025. Cancer Cell. Read More

Furudate K and Takahashi K. Prenatal Chemotherapy and Its Impact on the Genome of Fetal Hematopoiesis. 2025. Cancer Discovery. Read More

Kim W, Crosse E, Neef E et al. Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias. 2025. Cell. Read More

Ebright R, Dilly J, Shaw A et al. Response and Resistance to RAS Inhibition in Cancer. 2025. Cancer Discovery. Read More

Marasco M, Kumar D, Garcia Borrego S et al. Direct Inhibition of RAS Reveals the Features of Oncogenic Signaling Driven by RAS G12 and Q61 Mutations. 2025. Cancer Discovery. Read More

Uryu H, Saeki K, Haeno H et al. Clonal evolution of hematopoietic stem cells after autologous stem cell transplantation. 2025. Nature Genetics. Read More

Huang J, Yuan C, Jiang J et al. Bridging cell morphological behaviors and molecular dynamics in multi-modal spatial omics with MorphLink. 2025. Nature Communications. Read More

Weller C, Burnett L, Jiang L et al. A neomorphic protein interface catalyzes covalent inhibition of RASG12D aspartic acid in tumors. 2025. Science. Read More

Li T, Akhtarkhavari S, Qi S et al. Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment. 2025. Advanced Biology. Read More

Broderick C, Mezzadra R, Sisso E et al. A RAS(ON) multi-selective inhibitor combination therapy triggers long-term tumor control through senescence-associated tumor-immune equilibrium in PDAC. 2025. Cancer Discovery. Read More

Moufarrij S, Hazimeh D, Rockwell T et al. Gauging the Magnitude of Missed Opportunity for Ovarian Cancer Prevention. 2025. JAMA Surgery. Read More

Kegyes D, Teodorescu P, Supeanu T et al. Arsenic trioxide for reprogramming the bone marrow microenvironment to eliminate acute myeloid leukemia blasts. 2025. HemaSphere. Read More

Johnson J, Bergman D, Rocha H et al. Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories. 2025. Cell. Read More

Morris V, Parseghian C, Bahrambeigi V et al. Phase 1/2 trial of encorafenib, cetuximab, and nivolumab in microsatellite stable BRAFV600E metastatic colorectal cancer. 2025. Cancer Cell. Read More

Chidambaram S, Stone R, Roche K et al. A Role for General Surgery in Saving Lives from Ovarian Cancer. 2025. Journal of the American College of Surgeons. Read More

McAndrews K, Paradiso F, Stalnecker C et al. An allele-agnostic mutant-KRAS inhibitor suppresses tumor maintenance signals and reprograms tumor immunity in pancreatic cancer. 2025. Science Translational Medicine. Read More

Guo J, Gong D, Evans K et al. Integrative genomic identification of therapeutic targets for pancreatic cancer. 2025. Cell Reports. Read More

Knisely A, Dai Y, Barlow G et al. Surgical and blood-based minimal residual disease in patients with ovarian cancer after frontline therapy: Clinical outcomes and translational opportunities. 2025. Clinical Cancer Research. Read More

Michmerhuizen N, Heikamp E, Iacobucci I et al. KAT6A and KAT7 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia. 2025. Cancer Discovery. Read More

Blackstone E, Weeks L, DeZern A et al. Ethical Considerations for Hematologic Precursor Conditions. 2025. Blood Advances. Read More

2025 PRE-PRINT

Yu K, Abou-Mrad Z, Törkenczy K et al. A pathogenic subpopulation of human glioma associated macrophages linked to glioma progression. 2025. (pre-print bioRxiv). Read More

Tosh C, Zhang B, Tansey W. Treatment response as a latent variable. 2025. (pre-print arrxiv). Read More

Mahadevan K, Maldonado A, Li B et al. Inhibitors of oncogenic Kras specifically prime CTLA4 blockade to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancer. 2025. (pre-print biorxiv). Read More

Dalin S, Webster S, Sugawara N et al. Mutations and structural variants arising during double-strand break repair. 2025. (pre-print biorxiv). Read More

Gaglione S, Mukkamala R, Krishna C, et al. Scalable TCR synthesis and screening enables antigen reactivity mapping in vitiligo. 2025. (pre-print biorxiv). Read More

Alberti M, Srivatsan S, Shao J et al. U2af1S34F and U2af1Q157R myeloid neoplasm-associated hotspot mutations induce distinct hematopoietic phenotypes in mice. 2025. (pre-print Research Square). Read More

McCurry D, Ge Z, Lee J et al. ASXL1 truncating mutations drive leukemic resistance to T cell attack. 2025. (pre-print biorxiv). Read More

Forjaz A, Romero V, Reucroft I et al. PIVOT: an open-source tool for multi-omic spatial data registration. 2025. (pre-print biorxiv). Read More

Cho Y, Lee J, Shin S et al. Modeling cellular influence delineates functionally relevant cellular neighborhoods in primary and metastatic pancreatic ductal adenocarcinoma. 2025. (pre-print biorxiv). Read More

Bernard V, Ku L, Wang T et al. A spatial atlas of chemoradiation therapy in pancreatic cancer identifies cellular and microenvironmental determinants of persister populations. 2025. (pre-print biorxiv). Read More

Chang T, Chien Y, Chen S et al. Integrated Spatial Analysis of Ovarian Precancerous Lesions. 2025. (pre-print biorxiv). Read More

McAndrews K, Mahadevan K, Li B et al. CDK8 remodels the tumor microenvironment to resist the therapeutic efficacy of targeted KRASG12D inhibition in pancreatic ductal adenocarcinoma. 2025. (pre-print biorxiv). Read More

Dacoba T, Douglas-Green S, Murthy B et al. Layer-by-Layer Nanoparticle Outer Polyion Impacts Protein Corona Formation. 2025. (pre-print biorxiv). Read More

Kulej K, Steinberg A, Zhang J et al. End-to-end proteogenomics for discovery of cryptic and non-canonical cancer proteoforms using long-read transcriptomics and multi-dimensional proteomics. 2025. (pre-print biorxiv). Read More

Mahadevan K, Maldonado A, Li B et al. Distinct small molecule inhibitors of Kras specifically prime CTLA4 blockade therapy to transcriptionally reprogram Tregs and overcome resistance to suppress pancreas cancer. 2025. (pre-print biorxiv). Read More

2024 PUBLISHED

Adjei N, Haas A, Sun C, et al. Cost of ovarian cancer by the phase of care in the United States. 2024. American Journal of Obstetrics & Gynecology Read More

Aguirre A, Stanger B, Maitra A, et al. Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer. 2024. Cancer Research. Read More

Bahrambeigi V, Lee J, Branchi V, et al. Transcriptomic Profiling of Plasma Extracellular Vesicles Enables Reliable Annotation of the Cancer-Specific Transcriptome and Molecular Subtype. 2024. Cancer Research. Read More

Braxton A, Kiemen A, Grahn M, et al. 3D genomic mapping reveals multifocality of human pancreatic precancers. 2024. Nature. Read More

Chien Y, Wang Y, Huang P, et al. Morphologic and Molecular Heterogeneity of High-grade Serous Carcinoma Precursor Lesions. 2024. The American Journal of Surgical Pathology. Read More

Dilly J, Hoffman M, Abbassi L, et al. Mechanisms of resistance to oncogenic KRAS inhibition in pancreatic cancer. 2024. Cancer Discovery. Read More

Jiang J, Liu Y, Qin J, et al. METI: deep profiling of tumor ecosystems by integrating cell morphology and spatial transcriptomics. 2024. Nature Communications. Read More

Kiemen A, Wu P, Braxton A, et al. Power-law growth models explain incidences and sizes of pancreatic cancer precursor lesions and confirm spatial genomic findings. 2024. Science Advances. Read More

Shi H, Williams M, Satas G, et al. Allele-specific transcriptional effects of subclonal copy number alterations enable genotype-phenotype mapping in cancer cells. 2024. Nature Communications. Read More

Singhal A, Styers H, Rub J, et al. A classical epithelial state drives acute resistance to KRAS inhibition in pancreas cancer. 2024. Cancer Discovery. Read More

Wang Y, Douville C, Chien Y, et al. Aneuploidy Landscape in Precursors of Ovarian Cancer. 2024. Clinical Cancer Research: An Official Journal of the American Association for Cancer Research. Read More

Wasko U, Jiang J, Dalton T, et al. Tumor-selective activity of RAS-GTP inhibition in pancreatic cancer. 2024. Nature. Read More

Yen, J Wu T, Stone R, et al. Salpingectomy for ectopic pregnancy reduces ovarian cancer risk—a nationwide study. 2024. JNCI Cancer Spectrum. Read More

Zhang D, Schroeder A, Yan H, et al. Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology. 2024. Nature Biotechnology. Read More

2024 PRE-PRINT

Chukwu W, Lee S, Crane A, et al. Comparison of germline and somatic structural variants in cancers reveal systematic differences in variant generating and selection processes. 2024. (preprint – bioRxiv) Read More

Huang J, Yuan C, Jiang J, et al. MorphLink: Bridging Cell Morphological Behaviors and Molecular Dynamics in Multi-modal Spatial Omics. 2024. (preprint – bioRxiv) Read More

Kiemen A, Almagro-Pérez C, Matos V, et al. 3D histology reveals that immune response to pancreatic precancers is heterogeneous and depends on global pancreas structure. 2024. (preprint – bioRxiv) Read More

Uryu H, Saeki K, Haeno H, et al. Clonal evolution of hematopoietic stem cells after cancer chemotherapy. 2024. (preprint – bioRxiv) Read More

Wala J, Bruijn I, Coy S, et al. Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers. 2024. (preprint – bioRxiv) Read More

Williams M, Vazquez-Garcia I, Tam G, et al. Tracking clonal evolution of drug resistance in ovarian cancer patients by exploiting structural variants in cfDNA. 2024. (preprint – bioRxiv) Read More

Xu E, Smith B, Alberto W, et al. Peptide-MHC-targeted retroviruses enable in vivo expansion and gene delivery to tumor-specific T cells. 2024. (preprint – bioRxiv) Read More

Zhang C, Pellman D, et al. Chromosome breakage-replication/fusion enables rapid DNA amplification. 2024. (preprint – bioRxiv) Read More

Zhang H, Sashittal P, Karnoub E, et al. Genomic evolution of pancreatic cancer at single-cell resolution. 2024. (preprint – bioRxiv) Read More

2023 PUBLISHED

Han J, Xu J, Liu Y, et al. Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer. 2023. Genes & Development. Read More

Jazaeri A, Grisham R, Knisely A, et al. Transforming ovarian cancer care by targeting minimal residual disease. 2023. Med. Read More

Mahadevan K, LeBleu V, Ramirez E, et al. Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells. 2023. Developmental Cell. Read More

Mahadevan K, McAndrews K, LeBleu V, et al. KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells. 2023. Cancer Cell. Read More

Stone R, Sakran J, Long Roche K, et al. Salpingectomy in Ovarian Cancer Prevention. 2023. JAMA. Read More

Taylor M, Wu C, Fridy P, et al. Ultrasensitive Detection of Circulating LINE-1 ORF1p as a Specific Multicancer Biomarker. 2023. Cancer Discovery. Read More

Zhang H, Hunter M, Chou J, et al. BayesTME: An end-to-end method for multiscale spatial transcriptional profiling of the tissue microenvironment. 2023. Cell Systems. Read More

Zhao Y, O’Keefe C, Hsieh K, et al. Multiplex Digital Methylation‐Specific PCR for Noninvasive Screening of Lung Cancer. 2023. Advanced Science. Read More

2023 PRE-PRINT

Brodeur M, Dopeso H, Zhu Y, et al. Interferon response and epigenetic modulation by SMARCA4 mutations drive ovarian tumor immunogenicity. 2023. (preprint – bioRxiv) Read More

Dalin S, Webster S, Sugawara N, et al. Double-strand break repair-associated intragenic deletions and tandem duplications suggest the architecture of the repair replication fork. 2023. (preprint – bioRxiv) Read More

Mahadevan K, McAndrews K, LeBleu V, et al. Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination with immunotherapy regresses advanced PDAC in a CD8+ T cells dependent manner. 2023. (preprint – bioRxiv) Read More

Perelli L, Zhang L, Mangiameli S, et al. Evolutionary fingerprints of EMT in pancreatic cancers. 2023. (preprint – bioRxiv) Read More

Rendo V, Schubert M, Khuu N, et al. A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer. 2023. (preprint – bioRxiv) Read More

Yu K, Basu S, Baquer G, et al. Investigative needle core biopsies for multi-omics in Glioblastoma. 2023. (preprint – medRxiv) Read More

2022 PUBLISHED

Chatterjee F, Duong E, Bhutkar A, et al. 994 Investigating the ability of tumor cell-derived type I interferon to potentiate anti-ovarian cancer immune responses. 2022. Journal for ImmunoTherapy of Cancer. Read More

Liberto J, Chen S, Shih I, et al. Current and Emerging Methods for Ovarian Cancer Screening and Diagnostics: A Comprehensive Review. 2022. Cancers. Read More

Mandal J, Mandal P, Wang T, et al. Treating ARID1A mutated cancers by harnessing synthetic lethality and DNA damage response. 2022. Journal of Biomedical Science. Read More

2022 PRE-PRINT

Kinny-Köster B, Guinn S, Tandurella J, et al. Inflammatory Signaling in Pancreatic Cancer Transfers Between a Single-cell RNA Sequencing Atlas and Co-Culture. 2022. (preprint – bioRxiv) Read More

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